LunaX™ TissueMatrix is a tunable ECM tailored for 3D spheroid and co-culture models of mesodermal origin, including stromal and endothelial cell types. Suitable for applications in oncology, vasculogenesis, and drug screening, it offers high reproducibility and intuitive handling - ideal for both expert users and researchers transitioning from 2D to 3D systems. LunaX™ tunable hydrogels are engineered to enable precise modulation of ECM stiffness while preserving cellular viability and function. Crosslinking is driven by a photoinitiator that undergoes activation upon exposure to cytocompatible blue visible light (λ = 405nm), initiating a controlled polymerisation reaction. Stiffness can be incrementally increased by extending the duration of light exposure, allowing fine-tuned adjustment of the mechanical microenvironment. This approach facilitates the generation of physiologically relevant 3D models that recapitulate tissue-specific or disease-associated ECM mechanics, including progressive stiffening observed in tumorigenesis and fibrosis.

• Ready-to-use format
• Precise mechanical control - photocrosslinking technology enables tunable stiffness for optimized 3D cell culture conditions.
• High bioactivity - supports cell attachment, proliferation, and proteolytic degradation, promoting physiologically relevant cell behaviour
• Optically transparent for imaging - forms optically clear hydrogels that remain stable at room temperature, ensuring seamless integration with standard imaging systems and bioassays.
• Reliable and reproducible ECM for 3D cell culture

Each kit contains everything you need for precise, tunable 3D cell culture.

• SKU0005 low stiffness kit (0 - 6.5kPa):
• 5mL LunaGel™ ECM (2x solution)
• 5 vials of freeze-dried cytocompatible photoinitiator
• SKU00009 high stiffness kit (0 - 25 kPa):
• 5mL LunaGel™ ECM (1.5x solution)
• 5 vials of freeze-dried cytocompatible photoinitiator