Interleukin-34 (IL-34) is a cytokine involved in regulating the differentiation, survival, and activation of monocytes, macrophages, and osteoclasts. IL-34 plays a key role for the development and maintenance of tissue-resident macrophages such as Langerhans cells in the skin and microglia in the brain. Recombinant IL-34 can be used in the differentiation of induced pluripotent stem cells (iPSC) to microglia.
Qkine have optimized the sequence and manufacture of IL-34 PLUS™ to produce a highly and consistently bioactive protein (patent pending GB 2514413.0). Qk091 has a molecular weight of 25 kDa as a monomer and is supplied as a non-covalent dimer, highly pure, animal origin-free, tag free and carrier free for reproducible microglial differentiation and immune cell culture.
- High purity optimized human IL-34 protein (Uniprot: Q6ZMJ4)
- 25 kDa (monomer)
- >98%, by SDS-PAGE quantitative densitometry
- Animal origin-free (AOF) and carrier protein-free
- Expressed in E. coli
- Manufactured in our Cambridge, UK laboratories
- Lyophilized from acetonitrile, TFA
- Resuspend in sterile-filtered water at >50 µg/ml, add carrier protein if desired, prepare single use aliquots and store frozen at -20 °C (short-term) or -80 °C (long-term)
Products are for research use only and not for diagnostic or therapeutic use.
**Vial images are representative**
This product has met the following criteria to qualify for the following awards: