Interleukin-2/Fc, >98% (SDS-PAGE), recombinant, expressed in CHO cells, solution

Not available outside of the UK & Ireland.

Analysis Note

The biological activity is measured in a cell proliferation assay using CTLL2 cells.

Biochem/physiol Actions

IL-2 (interleukin-2) is a cytokine which is involved in the differentiation of T cell and natural killer (NK) cell, T cell memory, activation-induced lymphocyte cell death. The protein also has a role in regulatory T cell (Treg) development and homeostasis. It is linked with the risk of Grave′s disease, rheumatoid arthritis, celiac disease, multiple sclerosis, psoriasis, Crohn′s disease, ulcerative colitis and type-1 diabetes (T1D).

Possesses the biological functions of the IL-2 moiety and a prolonged circulating half-life determined by the Fc domain.

Other Notes

Dimeric fusion protein consisting of mouse IL-2 fused to mutant mouse IgG2a Fc.

Physical form

Solution in 0.2 µm filtered phosphate buffered saline, pH 7.4.