Trichloromethyl chloroformate, >=97.0% (GC)

Not available outside of the UK & Ireland.

Application

Trichloromethyl chloroformate (TCF) is an effective alternative to phosgene. It can react with amines, amino acids and amino alcohols to give the corresponding isocyanates, isocyanato acid chlorides and isocyanato chloroformates. TCF can also be used: To synthesize N-carboxy α-amino acid anhydrides.As an acylating agent to synthesize oxazolidinones from α-amino alcohols.As a dehydrating agent to synthesize aromatic diisocyanides in the presence of triethylamine.

Reactant for preparation of: Cyclic carbamimidates using a monophosphine gold(i) catalyst N-Alkenyl and cycloalkyl carbamates as dual acting histamine H3 and H4 receptor ligands Prostate-specific membrane antigen-targeted anticancer prodrugs Potential west nile virus protease inhibitors Antibody-drug conjugates (ADCs) Erythromycin A derivatives

Other Notes

Easy to handle substitute for phosgene; In-situ charcoal-catalyzed decomposition to phosgene and reaction with amino acids to N-carboxy anhydrides

Packaging

10, 50 mL in glass bottle