Non disponible en dehors du Royaume-Uni et de l'Irlande
Analysis Note
Color (visual): white to slight yellow to light redAppearance of substance (visual): powderIdentity (IR): passes testPurity (TLC(CMA1)): ≥ 98 %Assay (HPLC, area%): ≥ 95.0 % (a/a)Solubility (1 mmole in 2 ml DMF): clearly solubleFor TLC-Systems see our General Catalog
General description
Fmoc-ACA-OH is a useful tool for the SPPS of AMC fluorogenic protease substrates. Fmoc-ACA-OH [1] must be first loaded onto a Wang-type resin. Any unreacted linker hydroxyls must be capped using acetic anhydride. Following Fmoc removal, the first amino acid should be coupled withy HATU/collidine [2]. Insertion of ACA into the middle of a peptide provides fluorogenic substrates for endopeptidases [3]. Treatment of the ACC peptide obtained after TFA cleavage with aqueous base causes facile decarboxylation and formation of the AMC peptide.
Legal Information
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
Packaging
250 mg in Plastic bottle
1 g in Glass bottle
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