L-Thyroxine-13C6 solution, 100 mug/mL in methanol with 0.1N NH3, ampule of 1 mL, certified reference material

Not available outside of the UK & Ireland.

Application

The Certified Reference Material (CRM) in solution can also be used as an internal standard as follows: Combination of hollow fiber-liquid-phase microextraction (HF-LPME) based sample preparation and liquid chromatography-tandem mass spectrometric (LC-MS/MS) determination of total thyroxine in serum samples Development of an LC-MS/MS method for the multi-residue analysis of melatonin, cortisol, triiodothyronine, thyroxine, and testosterone in rat serum samples following their dual liquid-liquid extraction Simultaneous determination of thyroxine by an isotope dilution-matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) method from human serum samples Estimation of thyroxine (T₄) and triiodothyronine (T₃) in rat cardiac tissue samples by a high-performance liquid chromatographic-tandem mass spectrometric (HPLC-MS/MS) method following their derivatization Establishing and validating an LC-MS/MS-based method for the quantification of endogenous thyroid hormones, T₄ and two of its T₃ isomers, in tissue samples obtained from lamprey, following the enzymatic digestion and protein precipitation of the samples

Features and Benefits

Fully characterized under ISO/IEC 17025 and ISO 17034 accreditation Accompanied with a comprehensive Certificate of Analysis (CoA) with data on stability, homogeneity, accuracy of concentration, uncertainty, and traceability Rigorously tested through real-time stability studies to ensure accuracy and shelf life Gravimetrically prepared using qualified precision balances to ensure minimal uncertainty Flame sealed under argon into ampoules for long-term shelf life Offered in a convenient, DEA-exempt format to improve laboratory efficiency

General description

This internal standard and Certified Spiking Solution^® is suitable for quantitation of free and total T₄ serum levels by LC-MS/MS for determination of hyper- or hypothyroidism and monitoring treatment with synthetic thyroid hormones.L-Thyroxine-¹³C₆ is an isotopically labeled form of the tyrosine-based thyroid hormone, thyroxine (T₄). Thyroxine is secreted by the thyroid gland and is involved in different biological processes, such as growth, neurodevelopment, carbohydrate & oxygen metabolism, and protein synthesis

Legal Information

CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Cerilliant Corporation

CERILLIANT is a registered trademark of Cerilliant Corporation