Naringin, >=95% (HPLC)

Not available outside of the UK & Ireland.

Application

Naringin has been used: as a bitter tastant to compare the behavioral response of the Drosophila larva and adult(2) to study its anti-inflammatory property and to determine its effect on nucleus pulposus (NP) cells(3) to determine its effect on bone metabolism like osteogenic differentiation, inhibition of osteoclast formation(4)

Biochem/physiol Actions

Naringin can interact with signaling molecules and modulates signaling pathways. It possesses anti-inflammatory and anti-cancer activities. It also exhibits pharmacological effects on oxidative stress, bone regeneration, genetic damage, metabolic syndrome and central nervous system (CNS) diseases.

Naringin, a flavanoid in grapefruit and other citrus fruits, potently inhibits intestinal organic anion-transporting polypeptide 1A2 (OATP1A2). Grapefruit juice thereby reduces bioavailability of many pharmacological agents taken at the same time.