Violacein from Janthinobacterium lividum, and deoxyviolacein, HPLC), >98% (violacein (minimum 85% violacein) and deoxyviolacein, HPLC)

Not available outside of the UK & Ireland.

Application

Violacein from Janthinobacterium lividum has been used:for cell culture assaysas a standard to determine the crude violacein concentration in ethanol extracts of D. violaceinigra str. NI28 culturesas a standard to identify violacein in the leaf samples of Nicotiana

Biochem/physiol Actions

Violacein, a violet pigment, is an indole derivative produced by various bacterial strains such as Chromobacterium violaceum, Janthinobacterium lividum, Chromobacterium lividum, and Pseudoalteromonas luteoviolacea. Violacein is a member of a novel class of cytotoxic drugs, which mediate apoptosis. Violacein exhibits antitumoral, antibacterial, antiulcerogenic, antileishmanial, and antiviral activities. Violacein and its β-cyclodextrin complexes trigger apoptosis and differentiation in HL60 leukemic cells. Violacein cytotoxicity is preceded by activation of caspase 8, transcription of NF-κB target genes, and p38-MAPK activation resembling TNF-α signal transduction.

General description

Violacein from Janthinobacterium lividum is used as a colorant for natural and synthetic fabrics. It functions as a respiratory pigment and regulates tryptophan production. Violacein exhibits anti-protozoal activity.