R(+)-Verapamil monohydrochloride hydrate, >=98% (HPLC), powder

Code: V106-5MG D2-231

Not available outside of the UK & Ireland.

Application

R(+)-Verapamil monohydrochloride hydrate has been used as a P-glycoprotein (gp) inhibitor, to detect P-gp expression on the SK-OV-3 and SK-OV-3/DDP cell ...


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Your Price
$310.97 5MG
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Not available outside of the UK & Ireland.

Application

R(+)-Verapamil monohydrochloride hydrate has been used as a P-glycoprotein (gp) inhibitor, to detect P-gp expression on the SK-OV-3 and SK-OV-3/DDP cell surface by flow cytometry. It has also been used as a calcium channel blocker, to evaluate its effect on doxorubicin (DOX) cytotoxicity.

Biochem/physiol Actions

Verapamil is a calcium channel blocker. Verapamil hydrochloride is a phenyl-alkyl amine derivative and is potentially used for treating hypertension, angina pectoris and arrhythmias. It is water soluble in nature.

Inhibitor of P-glycoprotein; less active enantiomer of (±)-verapamil.

Caution

hygroscopic

Packaging

5, 25 mg in glass bottle

assay≥98% (HPLC)
colorwhite
formpowder
InChI keyICKXRKHJKXMFLR-KFSCGDPASA-N
InChI1S/C27H38N2O4.ClH.H2O/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H;1H2/t27-;;/m1../s1
optical activity[α]22/D +9.6°, c = 0.5 in ethanol(lit.)
Quality Level100
SMILES stringO.Cl.COc1ccc(CCN(C)CCC[C@@](C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC
solubilityethanol: soluble, H2O: >30 mg/mL
storage conditiondesiccated
Cas Number38176-02-2
Hazard Class6.1
Un Number2811
Pack Group3
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