Timolol maleate salt, >=98% (TLC), powder

Code: T6394-100MG D2-231

Not available outside of the UK & Ireland.

Application

Timolol maleate has been used as an adrenergic β-blocker for evaluating cardiovascular functions in mice5. It has also been used for evaluating th...


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$203.28 100MG
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Not available outside of the UK & Ireland.

Application

Timolol maleate has been used as an adrenergic β-blocker for evaluating cardiovascular functions in mice5. It has also been used for evaluating the uptake of 86Rb+ in rat cardiomyocytes6.

Biochem/physiol Actions

Timolol maleate is a class II anti-arrhythmic agent that functions as a non-selective β-adrenoceptor antagonist, a vasodilator and an anti-glaucoma agent. Studies have reported that timolol maleate can be used for the treatment of infantile hemangioma (IH)7.

Features and Benefits

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Preparation Note

Timolol maleate is soluble in ethanol and water.

ε (extinction coefficient)8,700 at 294 nm at 1 M
assay≥98% (TLC)
colorwhite to off-white
formpowder
Gene Informationhuman ... ADRB1(153), ADRB2(154), ADRB3(155)
InChI keyWLRMANUAADYWEA-NWASOUNVSA-N
InChI1S/C13H24N4O3S.C4H4O4/c1-13(2,3)14-8-10(18)9-20-12-11(15-21-16-12)17-4-6-19-7-5-17;5-3(6)1-2-4(7)8/h10,14,18H,4-9H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t10-;/m0./s1
mp202-203 °C (lit.)
optical activity[α]25/D -5.4°, c = 4.9 in 1 M HCl(lit.)
originatorMerck & Co., Inc., Kenilworth, NJ, U.S.
Quality Level200
SMILES string[H]C(=C(/[H])C(O)=O)C(O)=O.CC(C)(C)NC[C@H](O)COc1nsnc1N2CCOCC2
solubilityethanol: soluble, H2O: soluble
Cas Number26921-17-5
This product has met the following criteria to qualify for the following awards:



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