Trapoxin A, >=98% (HPLC), from Helicoma ambiens

Not available outside of the UK & Ireland.

Application

Trapoxin A has been used:to study its effects on the inhibition of histone deacetylase 11 (HDAC11)to study its effects on the inhibition of HDAC3 in human cell linesto study its effects on the inhibition of HDAC6 in rat pyramidal neurons

Biochem/physiol Actions

Trapoxin A is a cyclotetrapeptide and a histone deacetylase (HDAC) inhibitor. It increases the level of chromatin acetylation associated with histone H3 at low nanomolar concentrations. Unlike the reversible HDAC inhibition induced by TCA, Trapoxin A irreversibly inhibites HDAC activity in crude cell lysates, and induces the accumulation of hyperacetylated core histones in a number of mammalian cell lines and tissues. Histone acetylation and methylation have been studied extensively for their anti-tumor activities in carcinogenesis and Trapoxin has been suggested as a potential anticancer agent for pre-clinical trials.

Features and Benefits

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Preparation Note

Trapoxin A is soluble in DMSO at a concentration ranging from 0.9-1.10 mg/ml and yields a clear, colorless to faint yellow solution. It is also soluble in chloroform and methanol.