Calhex 231 hydrochloride, >=98% (HPLC)

Not available outside of the UK & Ireland.

Application

Calhex 231 hydrochloride has been used:as a calcium-sensing receptor (CaSR) antagonist: to test its impact on hearing in rats to test its effect on blood pressure levels spontaneous hypertensive rats (SHRs)to test its effect on acoustic response bias in zebrafish in Caco-2 cells to test its effect on, overexpression of fibroblast growth factor-23 (FGF-23 )

Biochem/physiol Actions

Calhex 231 is a negative allosteric modulator of the calcium sensing receptor CaSR. Calhex 231 blocks calcium-induced accumulation of inositol phosphate with an IC₅₀ of 0.36 µM.

Packaging

5, 25 mg in glass bottle