Not available outside of the UK & Ireland.
Application
PF-429242 dihydrochloride has been used as an inhibitor of sterol regulatory element-binding protein (SREBP).
Biochem/physiol Actions
PF-429242 is a potent inhibitor of S1P (cellular proprotein convertase sterol regulatory element-binding protein (SREBP) site 1 protease) that reduces expression levels of hepatic SREBP target genes and lower rates of cholesterol and fatty acid synthesis in mice. PF-429242 is a potent antiviral agent against prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) and LASV in cultured cells. PF-429242 efficiently prevented the processing of GPC from the LCMV and LASV. PF-429242 is expected to be active against CCHFV.
Packaging
5, 25 mg in glass bottle
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