GSK2578215A, >=98% (HPLC)

Code: SML0660-25MG D2-231

Not available outside of the UK & Ireland.

Biochem/physiol Actions

GSK2578215A stimulates mitochondrial fragmentation, autophagy and mitophagy.

GSK2578215A is a potent inhibitor of leucine-rich repeat kinase-2 (...


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Your Price
$598.44 25MG

Not available outside of the UK & Ireland.

Biochem/physiol Actions

GSK2578215A stimulates mitochondrial fragmentation, autophagy and mitophagy.

GSK2578215A is a potent inhibitor of leucine-rich repeat kinase-2 (LRRK2) also known as dardarin or PARK8, a kinase with mutations linked to Parkinson’;s disease. Because the most common mutation, G2019S, enhances LRRK2 kinase activity, it is hoped that LRRK2 inhibitors may be useful in treating the disease. GSK2578215A inhibited both wild-type and G2019S mutant LRRK2 kinase activity with IC50s of 10.9 and 8.9 nM respectively. It has good blood-brain barrier (BBB) permeability with a high ratio of brain to plasma distribution in mice.

Packaging

5, 25 mg in glass bottle

assay≥98% (HPLC)
colorwhite to beige
formpowder
Quality Level100
solubilityDMSO: 15 mg/mL, clear
storage temp.2-8°C
Cas Number1285515-21-0
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