GMX1778, >=98% (HPLC)

Not available outside of the UK & Ireland.

Application

GMX1778 has been used as NAMPT inhibitor, to study its effects on nicotinamide adenine dinucleotide (NAD) contents of SH-SY5Y cells exposed to Vacor.

Biochem/physiol Actions

GMX1778 (CHS-828) is a competitive inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) that exhibits a potent anticancer activity both in vitro and in vivo. GMX1778 exerts a cytotoxic effect by decreasing the cellular level of NAD+. GMX1778 increases intracellular ROS in cancer cells but does not induce ROS in normal cells.

GMX1778 can regulate redox status and has the ability to simulate ROS in cancer cells.

Packaging

5, 25 mg in glass bottle