T863, >=98% (HPLC)

Code: SML0539-5MG D2-231

Not available outside of the UK & Ireland.

Application

T863 has been used as a diglyceride acyltransferase (DGAT1) inhibitor:to provide the opportunity to precisely control the DGAT inhibitionto treat mouse embryonic ...


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Your Price
$183.08 5MG
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Not available outside of the UK & Ireland.

Application

T863 has been used as a diglyceride acyltransferase (DGAT1) inhibitor:to provide the opportunity to precisely control the DGAT inhibitionto treat mouse embryonic fibroblasts (MEFs) to analyse lipid droplet biogenesisto specifically block neutrallipid synthesisand lipid droplet formation in HT-1080 cellsto block lipid droplet (LD) formation

Biochem/physiol Actions

T863 is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis in cells. T863 causes weight loss, reduction in serum and liver triglycerides, and improved insulin sensitivity in obese mice.

Packaging

5, 25 mg in glass bottle

assay≥98% (HPLC)
colorwhite to beige
formpowder
InChI keyFUIYMYNYUHVDPT-HDJSIYSDSA-N
InChI1S/C22H26N4O3/c1-22(2)19(26-18-20(23)24-12-25-21(18)29-22)16-9-7-15(8-10-16)14-5-3-13(4-6-14)11-17(27)28/h7-10,12-14H,3-6,11H2,1-2H3,(H,27,28)(H2,23,24,25)/t13-,14-
Quality Level100
SMILES stringCC1(C)Oc2ncnc(N)c2N=C1c3ccc(cc3)[C@@H]4CC[C@H](CC4)CC(O)=O
solubilityDMSO: 15 mg/mL (clear solution)
storage temp.2-8°C
Cas Number701232-20-4
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