Ro 25-6981 maleate salt, >=98% (HPLC)

Not available outside of the UK & Ireland.

Application

Ro 25-6981 maleate salt has been used as a selective N-methylD-aspartate receptor subtype 2B (NR2B) blocker to study its effects on patch-clamp recordings of N-methylD-aspartate receptor subtype 2A (NR2A)-containing N-methylD-aspartate receptor (NMDAR) excitatory postsynaptic currents (EPSCs).

Biochem/physiol Actions

Ro 25-6981 maleate salt is a potent and selective antagonist of NMDA glutamate receptors containing the NR2B subunit with IC₅₀ values of .009 µM for NR2B vs. 52 µM for NR2A subunits. Ro 25-6981 has been shown to have neuroprotectant effects and to reduce inflammatory and neuropathic pain in rodent models.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Packaging

5, 25 mg in glass bottle