S3I-201, >=97% (HPLC)

Code: SML0330-5MG D2-231

Not available outside of the UK & Ireland.

Application

S3I-201 has been used as a signal transducer and activator of transcription 3 (STAT3) inhibitor: to confirm the role of STAT3 phosphorylation in interleukin (IL)-...


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Your Price
$127.89 5MG
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Not available outside of the UK & Ireland.

Application

S3I-201 has been used as a signal transducer and activator of transcription 3 (STAT3) inhibitor: to confirm the role of STAT3 phosphorylation in interleukin (IL)-33 production in lung epithelial cells and IL-22 mRNA expression in sorted group 3 innate lymphoid cells (ILC3s) to study the cellular response of STAT3 triggered by β-hexaclorocyclohexane (β-HCH) in various cell linesto examine the influence of STAT3 in response to angiotensin II (ang II) on induction of fibrotic proteins in kidney epithelial cells

Biochem/physiol Actions

Inhibition of signal transducer and activator of transcription 3 (STAT3) activity by S3I-201 may be a potential therapeutic strategy for hypertensive kidney disease.

S3I-201 is a cell-permeable Stat3 inhibitor that binds to the Stat3-SH2 domain, prevents Stat3 phosphorylation/activation, dimerization, and DNA-binding.

Packaging

5, 25 mg in glass bottle

assay≥97% (HPLC)
colorwhite to beige
formpowder
InChI keyHWNUSGNZBAISFM-UHFFFAOYSA-N
InChI1S/C16H15NO7S/c1-10-2-5-12(6-3-10)25(22,23)24-9-15(19)17-11-4-7-13(16(20)21)14(18)8-11/h2-8,18H,9H2,1H3,(H,17,19)(H,20,21)
Quality Level100
SMILES stringCc1ccc(cc1)S(=O)(=O)OCC(=O)Nc2ccc(C(O)=O)c(O)c2
solubilityDMSO: >10 mg/mL
storage temp.−20°C
Cas Number501919-59-1
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