3-Deazaneplanocin A hydrochloride, >=98% (HPLC)

Not available outside of the UK & Ireland.

Application

3-Deazaneplanocin A hydrochloride has been used to examine the potential involvement of autophagy and apoptosis in colorectal cancer (CRC) cells.

3-Deazaneplanocin A hydrochloride has been used to test its effect on ovarian tumor progression. It has also been used as a S-adenosyl homocysteine hydrolase (SAH) inhibitor in c33A2 cells.

Biochem/physiol Actions

3-Deazaneplanocin A (DZNep) is an S-Adenosylhomocysteine Hydrolase inhibitor and histone methyltransferase EZH2 inhibitor. It switches on repressed tumor suppressor genes and induces apoptosis by inhibiting the expression of EZH2.

Features and Benefits

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General description

3-Deazaneplanocin A hydrochloride is a carbocyclic analog of adenosine. It has antimetastaticproperty. It is used to treat Ebola virus disease, gastric cancer, myeloma and lymphoma.

Packaging

1, 5 mg in glass bottle