ABL127, >=98% (HPLC)

Code: SML0294-25MG D2-231

Not available outside of the UK & Ireland.

Biochem/physiol Actions

ABL127 is a potent and selective inhibitor of Protein phosphatase methylesterase-1 (PME-1 or PPME-1). IC50 values were 11.1 nM and 6.4 nM in MDA-MB-23...


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$732.33 25MG
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Not available outside of the UK & Ireland.

Biochem/physiol Actions

ABL127 is a potent and selective inhibitor of Protein phosphatase methylesterase-1 (PME-1 or PPME-1). IC50 values were 11.1 nM and 6.4 nM in MDA-MB-231 and HEK 293T cells with no activity detected against >50 other serine hydrolases. PME-1 regulates the methylesterification state of protein phosphatase 2A (PP2A) and is implicated in cancer and neurodegeneration.

Packaging

5, 25 mg in glass bottle

assay≥98% (HPLC)
colorcolorless
formfilm
InChI keyZRHWCAFAIHTQKD-KRWDZBQOSA-N
InChI1S/C17H20N2O5/c1-23-15(21)18-14(20)17(13-10-6-7-11-13,19(18)16(22)24-2)12-8-4-3-5-9-12/h3-5,8-9,13H,6-7,10-11H2,1-2H3/t17-/m0/s1
Quality Level100
SMILES stringO=C1[C@](C2=CC=CC=C2)(C3CCCC3)N(C(OC)=O)N1C(OC)=O
solubilityDMSO: ≥5 mg/mL
storage temp.2-8°C
Cas Number1073529-41-5
This product has met the following criteria to qualify for the following awards:



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