WEB2086, >=98% (HPLC)

Code: SML0238-5MG D2-231

Not available outside of the UK & Ireland.

Biochem/physiol Actions

WEB 2086 inhibits PAF mediated chemotaxis and leukotriene C4 production in eosinophils. It prevents surge in airway resistance and cardiovascular side...


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$184.43 5MG
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Not available outside of the UK & Ireland.

Biochem/physiol Actions

WEB 2086 inhibits PAF mediated chemotaxis and leukotriene C4 production in eosinophils. It prevents surge in airway resistance and cardiovascular side effects mediated by PAF inhalation.

WEB2086 is a very potent, selective platelet-activating factor (PAF) antagonist (IC50 = 16 nM). WEB2086 inhibits the proliferation of tumor cells and slows tumor growth in xenograft tumor models, and has been shown to inhibit angiogenesis.

Features and Benefits

This compound is featured on the PAF Receptor page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Packaging

5, 25 mg in glass bottle

assay≥98% (HPLC)
colorwhite to beige
formpowder
InChI keyJGPJQFOROWSRRS-UHFFFAOYSA-N
InChI1S/C22H22ClN5O2S/c1-14-25-26-19-13-24-21(16-4-2-3-5-18(16)23)17-12-15(31-22(17)28(14)19)6-7-20(29)27-8-10-30-11-9-27/h2-5,12H,6-11,13H2,1H3
Quality Level100
SMILES stringCc1nnc2CN=C(c3ccccc3Cl)c4cc(CCC(=O)N5CCOCC5)sc4-n12
solubilityDMSO: 10 mg/mL (clear solution)
storage conditiondesiccated
storage temp.2-8°C
Cas Number105219-56-5
This product has met the following criteria to qualify for the following awards:



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