PSB36, >=98% (HPLC)

Not available outside of the UK & Ireland.

Application

PSB36 was used to examine the role of A1-adenosine receptor-mediated cell signaling in CD39 expression in pancreatic b-cells of streptozotocin-induced diabetic mice.

Biochem/physiol Actions

PSB36 is a very potent, selective antagonist of the adenosine A1 receptor. The compound selectivity (Ki) for human A1, A2A, A2B and A3 receptors is 0.7, 980, 187 and 2300 respectively. PSB36 is considerably more potent that DPCPX (EC₅₀ 0.012 nM vs 2.9 nM)

Inhibition of A1 adenosine receptor by PSB36 modulates the spinal antinociception in animal models.

Features and Benefits

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Packaging

10, 50 mg in glass bottle