BMS - 299897, > = 98% (HPLC)

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

BMS-299897 has been used as an γ-secretase inhibitor to stop high glucose (HG) mediated amyloid β-peptide (Aβ) secretion.

Biochem/physiol Actions

BMS-299897 may be used as a therapeutic for Alzheimer′s disease.

BMS-299897 is a potent inhibitor of γ-secretase. The comound is 15-fold more selective for inhibiting the cleavage of β-amyloid precursor protein over Notch cleavage (IC₅₀s 7.1 and 105.9, respectively). In vivo, BMS-299897 blocks the formation of Aβ40 and Aβ42 in the brain and CSF without affecting maturation of CD8⁺ T cells or intestinal goblet cells, suggesting Notch signalling was not significantly inhibited.

Packaging

5, 25 mg in glass bottle