Non disponible en dehors du Royaume-Uni et de l'Irlande
Application
SIB 1757 may be used in mGluR5 metabotropic glutamate receptor-mediated cell signaling studies.
Biochem/physiol Actions
SIB 1757 is a highly selective mGluR5 metabotropic glutamate receptor antagonist. It non-competitively inhibits glutamate-induced increase in Ca2+ at human metabotropic glutamate receptor 1 (hmGluR1).1 Inhibition of mGlu5 receptor renders protection to neurons2 against methamphetamine-induced oxidative damage.3
Features and Benefits
This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Ce produit répond aux critères suivants pour être admissible aux récompenses suivantes :