S32826 disodium salt hydrate, >=98% (HPLC)

Code: S1825-25MG D2-231

Not available outside of the UK & Ireland.

Application

S32826, a potent inhibitor of autotaxin (ATX), may be used to identify and characterize the lyso-phospholipase D (lysoPLD, ATX) involved in bioactive lyso-phospha...


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$889.84 25MG
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Not available outside of the UK & Ireland.

Application

S32826, a potent inhibitor of autotaxin (ATX), may be used to identify and characterize the lyso-phospholipase D (lysoPLD, ATX) involved in bioactive lyso-phosphatidic acid (LPA) formation. S32826 may be used to help determine the role of ATX in malignant cell processes such as tumorigenesis, invasion, and metastases; cardia bifida and atherosclerosis.

Biochem/physiol Actions

S32826 is a potent inhibitor of autotaxin. Autotaxin is a newly discovered lyso-phospholipase D (lysoPLD). Autotaxin and lyso-phosphatidic acid (LPA) have been associated with early cancer progression and motility of cancer cells as well as with metastasis. Because of localization (adipose tissue), the enzyme might play an important role in diabetes and obesity. Autotaxin might be the only source of LPA. S32826 is the strongest inhibitor of autotaxin reported. The compound shows activity in cellular or ex vivo models.

Packaging

5, 25 mg in glass bottle

assay≥98% (HPLC)
colorwhite
formpowder
InChI keyDGRFALMFDGBLCP-UHFFFAOYSA-L
InChI1S/C21H36NO4P.2Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-21(23)22-20-16-14-19(15-17-20)18-27(24,25)26;;/h14-17H,2-13,18H2,1H3,(H,22,23)(H2,24,25,26);;/q;2*+1/p-2
Quality Level100
SMILES string[Na+].[Na+].CCCCCCCCCCCCCC(=O)Nc1ccc(CP([O-])([O-])=O)cc1
solubilityH2O: ≥10 mg/mL
storage conditiondesiccated
storage temp.−20°C
Cas Number1103672-43-0
This product has met the following criteria to qualify for the following awards:



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