R(+)-SKF-81297 hydrobromide, >=98% (HPLC), solid

Code: S179-5MG D2-231

Not available outside of the UK & Ireland.

Application

R(+)-SKF-81297 hydrobromide has used as D1-type dopamine receptor agonist: to test it effect on the spike firing in rat retinal ganglion cellsin human em...


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$947.72 5MG
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Not available outside of the UK & Ireland.

Application

R(+)-SKF-81297 hydrobromide has used as D1-type dopamine receptor agonist: to test it effect on the spike firing in rat retinal ganglion cellsin human embryonic kidney (HEK) 293T cellsto test its inhibitory effect in microglial cells

Biochem/physiol Actions

SKF-81297 administration in spontaneously hypertensive rats (SHR) induces an increase in expression of proto-oncogene c-fos mRNA leading to biphasic effect on locomotion. It favors the turnover of phosphoinositide and adenylyl cyclase. SKF-81297 is involved in the stimulation of neurons, in particular the postsynaptic striatal neurons.

Packaging

5 mg in glass bottle

assay≥98% (HPLC)
colorwhite to off-white
formsolid
InChI keyRMIJGBMRNYUZRG-BTQNPOSSSA-N
InChI1S/C16H16ClNO2.BrH/c17-15-11-6-7-18-9-13(10-4-2-1-3-5-10)12(11)8-14(19)16(15)20;/h1-5,8,13,18-20H,6-7,9H2;1H/t13-;/m1./s1
optical activity[α]22/D +15.14°, c = 0.52 in DMF(lit.)
Quality Level100
SMILES stringBr[H].Oc1cc2[C@H](CNCCc2c(Cl)c1O)c3ccccc3
solubilityH2O: 6 mg/mL, DMSO: soluble
storage conditionprotect from light, desiccated
Cas Number253446-15-0
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