Not available outside of the UK & Ireland.
Application
Photochemical reagent for the investigation of nucleic acid structure and function.
Psoralen has been used: as a crosslinker for dsRNA for in- situ hybridization studies in testing melanin dispersal effects in fish scale melanophores to test its stimulatory effects in osteoblast a cell proliferation assay as a reference standard in high-performance liquid chromatography (HPLC)
Biochem/physiol Actions
Psoralen belongs to the linear type furanocoumarins. It intercalates and induces interstrand cross-links in DNA. On UV exposure psoralen is excited leading to irreversible intercalation with DNA by covalent bond formation. This property of psoralen ultraviolet A light (PUVA) is exploited in treating skin diseases and cutaneous T-cell lymphoma. However, usage psoralen also leads to hepatotoxicity and cytotoxicity by the generation of psoralen photoproducts (POPs). It may be useful in treating osteoporosis
Features and Benefits
This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Packaging
10, 25, 100 mg in glass bottle
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