Phenylbutazone,

Not available outside of the UK & Ireland.

Application

Phenylbutazone has been used:as a hepatotoxin in transgenic zebrafish line (LiPan) hepatotoxin assayas a standard in high-performanceliquid chromatography-ultraviolet (HPLC-UV) methodas an anti-inflammatory compound in hen′s egg chorioallantoic membrane test (HET-CAM assay)

Biochem/physiol Actions

Phenylbutazone is a hepatotoxin and binds to plasma proteins. It is used to treat inflammation in horse. Phenylbutazone has potential to treat ankylosing spondylitis. It has therapeutic potential to treat myotonic dystrophy type 1 (DM1) by inducing muscle blind-like protein 1 (MBNL1) expression. It also favors the expression of muscle chloride channel in skeletal muscles.

Packaging

25, 100, 500 g in poly bottle

Substrates

Non-steroidal anti-inflammatory compound; inhibitor of cyclooxygenase that is also a substrate for peroxidation by cyclooxygenase.