Paxilline, powder, >=98% (TLC)

Code: P2928-5MG D2-231

Not available outside of the UK & Ireland.

Application

Paxilline has been used to block large conductance calcium activated potassium channels (BKCa) in murine smooth muscle cells and in myometrial cells of uterine sa...


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$275.97 5MG
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Not available outside of the UK & Ireland.

Application

Paxilline has been used to block large conductance calcium activated potassium channels (BKCa) in murine smooth muscle cells and in myometrial cells of uterine samples. Paxilline acts as an agonist and activates liver X receptor in atlantic salmon.

Biochem/physiol Actions

Paxilline is a selective blocker of high-conductance Ca2+-activated (Maxi-K) potassium channels. It also blocksbig potassium (BK) channels.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

General description

Paxilline is an indole diterpene metabolite produced by fungi. It has a functionalized pentacyclic core and is a template for the synthesis of a wide variety of derivatives.

Other Notes

Major toxin in Penicillium paxilli

Packaging

5, 10 mg in glass bottle

assay≥98% (HPLC)
colorfaintly yellow
formpowder
InChI keyACNHBCIZLNNLRS-UBGQALKQSA-N
InChI1S/C27H33NO4/c1-24(2,30)23-20(29)14-18-21(32-23)10-11-25(3)26(4)15(9-12-27(18,25)31)13-17-16-7-5-6-8-19(16)28-22(17)26/h5-8,14-15,21,23,28,30-31H,9-13H2,1-4H3/t15-,21-,23-,25+,26+,27+/m0/s1
Quality Level200
SMILES stringCC(C)(O)C1OC2CCC3(C)C(O)(CCC4Cc5c([nH]c6ccccc56)C34C)C2=CC1=O
storage temp.2-8°C
Cas Number57186-25-1
Hazard Class6.1
Un Number2811
Pack GroupII
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