NSC 663284, > = 98 %(HPLC) ,SOLIDE

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

NSC 663284 has been used as a cell division cycle 25(CDC25) inhibitor to study its effects on the level of kizuna (kiz) dephosphorylation. It has also been used as a control in horseradish peroxidase/phenol red based assay and resazurin-based redox assay.

Biochem/physiol Actions

Potent, irreversible, cell permeable and mixed competitive CDC25 phosphatase family inhibitor

NSC 663284 is a quinolinediones, which is involved in the inhibition of cell cycle progression at both G1 and G2/M phase. It is also involved in inhibiting the dephosphorylation and activation of cyclin-dependent kinases (Cdks) in vitro and in vivo. NSC 663284 stops the proliferation of various tumor cell lines.

Packaging

5, 25 mg in glass bottle