NH125, >=98% (HPLC), solid

Code: N2162-5MG D2-231

Not available outside of the UK & Ireland.

Analysis Note

IC50 = 60 nM for eEF-2 kinase vs protein kinase C (IC50= 7.5 µM), protein kinase A (IC50= 80 µM), and calmodulin-depe...


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$429.44 5MG
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Not available outside of the UK & Ireland.

Analysis Note

IC50 = 60 nM for eEF-2 kinase vs protein kinase C (IC50= 7.5 µM), protein kinase A (IC50= 80 µM), and calmodulin-dependent kinase II IC50 > 100 µM).

Biochem/physiol Actions

NH125 is a novel plant histidine kinase inhibitor and selective mammalian eurkaryotic elongation factor-2 kinase (eEF-2K).

NH125 exhibits anti-proliferation activity against many cancer cells. It also exhibits antibacterial effects by inhibiting bacterial histidine protein kinase.

Packaging

Packaged under nitrogen.

5, 25 mg in glass bottle

assay≥98% (HPLC)
colorwhite to off-white
formsolid
InChI keyRVWOHCBHAGBLLT-UHFFFAOYSA-M
InChI1S/C27H45N2.HI/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-19-22-28-23-24-29(26(28)2)25-27-20-17-16-18-21-27;/h16-18,20-21,23-24H,3-15,19,22,25H2,1-2H3;1H/q+1;/p-1
mp88.2-94.9 °C
Quality Level100
SMILES string[I-].CCCCCCCCCCCCCCCC[n+]1ccn(Cc2ccccc2)c1C
solubilityDMSO: >20 mg/mL
storage temp.−20°C
Cas Number278603-08-0
This product has met the following criteria to qualify for the following awards:



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