MDL 28170, >=95% (HPLC)

Not available outside of the UK & Ireland.

Amino Acid Sequence

Z-Val-Phe-al

Application

MDL 28170 has been used as a calpain inhibitor:to study its effects on neuroinflammation and necroptosis in rat model of cardiac arrestto analyze its effects on the degradation of neuronal nitric oxide synthase (nNOS) in beef semimembranosus muscleto study its protective effects against traumatic brain injury and survival of bone marrow-derived mesenchymal stem cells (BMSCs) in rat brain

Biochem/physiol Actions

MDL 28170 exhibits neuroprotective effects against spinal cord injury, focal cerebral ischemia, and neonatal hypoxia-ischemia in rats. It also shows anti-inflammatory and anti-neurodegenerative properties. MDL 28170 crosses the blood-brain barrier and penetrates readily through the cell membranes.

MDL 28170 is a potent cell permeable calpain I and II inhibitor; reduces capsaicin-mediated cell death in cultured dorsal root ganglion neurons. Reduced occurrence of apoptosis in H₂O₂ and A23187 treated PC12 cells. γ-secretase-inhibitor.