Lactacystin, >=90% (HPLC)

Code: L6785-.2MG D2-231

Not available outside of the UK & Ireland.

Application

Lactacystin has been used:as a proteasome inhibitor to inhibit protein degradationto inhibit proteasomal activity of cells for live cell imagingto block proteasom...


 Read more

Your Price
$539.83 EACH
REQUEST

Not available outside of the UK & Ireland.

Application

Lactacystin has been used:as a proteasome inhibitor to inhibit protein degradationto inhibit proteasomal activity of cells for live cell imagingto block proteasomal proteolysis in human monocyte-derived dendritic cells (MoDCs) for 24 hto provide unilateral injection to animals to induce nigrostriatal lesions

Biochem/physiol Actions

Lactacystin can block the development of cell cycle and stimulate differentiation in a murine neuroblastoma cell line. It can serve as a precursor forclasto-lactacystin β-lactone. Cell-permeable and irreversible proteasome inhibitor (Ki = 4nM). Inhibits NF-kB activation (IC50 = 10mM). Induces neurite outgrowth in neuro2A mouse neuroblastoma cells.

General description

Lactacystin is an antibioticand a metabolite of Streptomycesspp.

assay≥90% (HPLC)
formpowder
InChI keyDAQAKHDKYAWHCG-RWTHQLGUSA-N
InChI1S/C15H24N2O7S/c1-6(2)10(19)15(11(20)7(3)12(21)17-15)14(24)25-5-9(13(22)23)16-8(4)18/h6-7,9-11,19-20H,5H2,1-4H3,(H,16,18)(H,17,21)(H,22,23)/t7-,9+,10+,11+,15-/m1/s1
potency4 nM Ki (proteasome inhibitor)
Quality Level200
SMILES stringCC(C)[C@H](O)[C@]1(NC(=O)[C@H](C)[C@@H]1O)C(=O)SC[C@H](NC(C)=O)C(O)=O
solubilitywater: 10 mg/mL, clear, colorless
storage temp.−20°C
Cas Number133343-34-7
This product has met the following criteria to qualify for the following awards:



PROCEED TO CHECKOUT

HAVE AN ACCOUNT? LOGIN
GUEST CHECKOUT

Proceed as a guest. You will have the option to register to access exclusive pricing and stock availability features after checkout.