Herbimycin A from Streptomyces hygroscopicus, >=95% (HPLC), powder

Code: H6649-.1MG D2-231

Not available outside of the UK & Ireland.

Application

Herbimycin A from Streptomyces hygroscopicus has been used as an inhibitor of Src tyrosine kinase in HEK293T cells and rat intestinal epithelial cells. I...


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Not available outside of the UK & Ireland.

Application

Herbimycin A from Streptomyces hygroscopicus has been used as an inhibitor of Src tyrosine kinase in HEK293T cells and rat intestinal epithelial cells. It has also been used to test its attenuation effect in intimal hyperplasia (IH) post balloon injury in rat carotid artery.

Biochem/physiol Actions

Herbimycin A is an inducer of heat shock protein (HSP). It increases HSP expression resulting in the attenuation of ischemia reperfusion induced pulmonary injury.

An antibiotic that inhibits protein tyrosine kinase. Herbimycin A is a potent inhibitor of angiogenesis.

Caution

Hygroscopic and photosensitive

General description

Herbimycin A from Streptomyces hygroscopicus is a benzoquinoidansamycinantibiotic. It is an analog of geldanamycin.

antibiotic activity spectrumviruses
assay≥95% (HPLC)
biological sourceStreptomyces hygroscopicus
coloryellow
formpowder
InChI keyMCAHMSDENAOJFZ-BVXDHVRPSA-N
InChI1S/C30H42N2O9/c1-16-10-9-11-23(37-5)28(41-30(31)36)18(3)12-17(2)27(40-8)24(38-6)13-19(4)26(39-7)21-14-20(33)15-22(25(21)34)32-29(16)35/h9-12,14-15,17,19,23-24,26-28H,13H2,1-8H3,(H2,31,36)(H,32,35)/b11-9-,16-10+,18-12+/t17-,19-,23-,24-,26+,27+,28-/m0/s1
mode of actionenzyme | inhibits
Quality Level200
SMILES stringCO[C@H]1C[C@H](C)[C@@H](OC)C2=CC(=O)C=C(NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(N)=O)C(C)=C[C@H](C)[C@H]1OC)C2=O
solubilityDMSO: 7.5 mg/mL (DMSO stock solution can be diluted in phosphate buffered saline. The ratio of buffer:DMSO should be greater than 500:1.)
storage temp.−20°C
Cas Number70563-58-5
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