FTI-277 trifluoroacetate salt, >=95% (HPLC), amorphous semi-solid

Code: F9803-1MG D2-231

Not available outside of the UK & Ireland.

Application

Farnesyltransferase inhibitor 277 (FTI-277) has been used to:inhibit protein farnesylation in breast cell lines.in marrow-isolated adult multilineage inducible ce...


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Your Price
$223.47 1MG
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Not available outside of the UK & Ireland.

Application

Farnesyltransferase inhibitor 277 (FTI-277) has been used to:inhibit protein farnesylation in breast cell lines.in marrow-isolated adult multilineage inducible cells (MIAMI).inhibition of farnesyl transferase in CV-1 in Origin with SV40 genes cells (COS-7).

Biochem/physiol Actions

Farnesyltransferase inhibitor 277 (FTI-277) mediates apoptosis in multiple myeloma and is regarded as a potential therapeutic agent.

Highly potent (pM/nM) Ras CAAX peptidomimetic which antagonizes both H and K-Ras oncogenic signaling. Inhibitor of farnesyltransferase (Ftase) IC50 = 50 nM.

Packaging

Very hygroscopic material, package in a dry room with deoxygenated MeOH and pump down the solvent. Store with desiccant.

1, 5 mg in glass bottle

assay≥95% (HPLC)
formfilm
InChI keyGJEFFRDWFVSCOJ-PXPMWPIZSA-N
InChI1S/C22H29N3O3S2.C2HF3O2/c1-28-22(27)20(10-11-30-2)25-21(26)18-9-8-17(24-13-16(23)14-29)12-19(18)15-6-4-3-5-7-15;3-2(4,5)1(6)7/h3-9,12,16,20,24,29H,10-11,13-14,23H2,1-2H3,(H,25,26);(H,6,7)/t16-,20+;/m1./s1
Quality Level100
shipped indry ice
SMILES stringOC(=O)C(F)(F)F.COC(=O)[C@H](CCSC)NC(=O)c1ccc(NC[C@@H](N)CS)cc1-c2ccccc2
solubilityH2O: ≥2 mg/mL
storage conditiondesiccated
storage temp.−70°C
Cas Number180977-34-8
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