R(+)-SCH-23390 hydrochloride, >=98% (HPLC), solid

Not available outside of the UK & Ireland.

Application

R(+)-SCH-23390 hydrochloride has been used:for intraperitoneal injection into experimental rats to study the role of D1 receptor in sensitizationas a D1 receptor-selective antagonist for intracranial drug infusionsas an antagonist of D1 receptor to study its effect on learning ability in fish

Biochem/physiol Actions

R(+)-SCH-23390 hydrochloride is a selective D1 dopamine receptor antagonist. It has greater binding capacity towards 5-hydroxytryptamine 2 (5-HT2) and 5-HT1C serotonin receptor subtypes in in vitro. R(+)-SCH-23390 has a half-life of about 25 minutes after administration. It is known to possess anti-stereotypic effect and cataleptogenic effect. It also has inhibitory effect on motor activity.

Features and Benefits

This compound is featured on the Dopamine Receptors and Potassium Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

Sold with the permission of Schering-Plough.

Packaging

5, 10, 25, 100 mg in glass bottle