Not available outside of the UK & Ireland.
Application
CK-869 has been used as an Arp2/3 complex inhibitor:to treat cultured mammalian cells and study its in vitro and in vivo effects on microtubule assemblyto induce membrane blebbing in HT1080 fibrosarcoma cellsto treat KDM3A-null cells and study the relation between actin dynamics and ciliogenesis
Biochem/physiol Actions
CK-0157869 (CK-869) prevents microtubule (MT) assembly, free of Arp2/3 complex.
CK-869 is a cell-permeable inhibitor of actin assembly mediated by the actin-related protein Arp2/3 complex of human and bovine, but not yeast. The actin-related protein Arp2/3 complex plays a major role in the regulation of the actin cytoskeleton. Apparently the compound binds to the hydrophobic core of Arp3 and alters its conformation.
Packaging
5, 25 mg in glass bottle
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