CHIC-35, >=97% (chiral, HPLC)

Code: C8742-5MG D2-231

Not available outside of the UK & Ireland.

Biochem/physiol Actions

CHIC-35 is cell-permeable, metabolically stable, and very potent inhibitor of SIRT1; IC50 of S-isomer is 60 nM; IC50 of mixed is...


 Read more

Your Price
$677.14 5MG
REQUEST

Not available outside of the UK & Ireland.

Biochem/physiol Actions

CHIC-35 is cell-permeable, metabolically stable, and very potent inhibitor of SIRT1; IC50 of S-isomer is 60 nM; IC50 of mixed isomers is 124 nM. There is no inhibition of SIRT3 or HDAC. The IC50 for SIRT2 is 2.77 µM. Sirtuins are protein deacetylases, which represent a new class of histone deacetylases (HDAC) involved in gene silencing. SIRT modulators are potential therapeutics for cancer, diabetes, muscle differentiation, heart failure, neurodegeneration, and aging.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Packaging

1, 5 mg in glass bottle

assay≥97% (chiral, HPLC)
formsolid
InChI keyABIVOOWWGYJNLV-JTQLQIEISA-N
InChI1S/C14H15ClN2O/c15-8-5-6-12-11(7-8)9-3-1-2-4-10(14(16)18)13(9)17-12/h5-7,10,17H,1-4H2,(H2,16,18)/t10-/m0/s1
Quality Level100
SMILES stringClC1=CC=C(NC2=C3CCCC[C@@H]2C(N)=O)C3=C1
solubilityH2O: ﹤2 mg/mL, DMSO: >10 mg/mL
storage temp.2-8°C
Cas Number848193-72-6
Hazard Class6.1
Un Number2811
Pack Group3
This product has met the following criteria to qualify for the following awards:



PROCEED TO CHECKOUT

HAVE AN ACCOUNT? LOGIN
GUEST CHECKOUT

Proceed as a guest. You will have the option to register to access exclusive pricing and stock availability features after checkout.