Calcipotriol hydrate, >=99% (HPLC)

Code: C4369-50MG D2-231

Not available outside of the UK & Ireland.

Biochem/physiol Actions

Calcipotriol, a synthetic derivative of calcitriol or Vitamin D, is used in the treatment of psoriasis and marketed under the trade name Dovonex. It h...


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$1,198.12 50MG
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Not available outside of the UK & Ireland.

Biochem/physiol Actions

Calcipotriol, a synthetic derivative of calcitriol or Vitamin D, is used in the treatment of psoriasis and marketed under the trade name Dovonex. It has comparable affinity with calcitriol (Vit. D) for the Vitamin D receptor (VDR), while being less than 1% as active as the calcitriol in regulating calcium metabolism. VDR belongs to the steroid/thyroid receptor superfamily, and is found on the cells of many different tissues including the thyroid, bone, kindney, and T cells of the immune system. Binding of calcipotriol to the VDR modulates the T cells gene transcription of cell differentiation and proliferation-related genes.

Packaging

10, 50 mg in glass bottle

assay≥98% (HPLC)
formpowder
InChI keyXBKHACNRWFKJNC-MANNPBRJSA-N
InChI1S/C27H40O3.H2O/c1-17(6-13-25(29)20-8-9-20)23-11-12-24-19(5-4-14-27(23,24)3)7-10-21-15-22(28)16-26(30)18(21)2;/h6-7,10,13,17,20,22-26,28-30H,2,4-5,8-9,11-12,14-16H2,1,3H3;1H2/b13-6+,19-7+,21-10-;/t17-,22-,23-,24+,25-,26+,27-;/m1./s1
Quality Level100
SMILES stringO.C[C@H](C=C[C@@H](O)C1CC1)C2CCC3C(CCC[C@]23C)=CC=C4C[C@@H](O)C[C@H](O)C4=C
solubilityDMSO: 15 mg/mL, clear
storage temp.room temp
Cas Number112965-21-6
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