A12B4C3, >=98% (HPLC)

Code: A8736-5MG D2-231

Not available outside of the UK & Ireland.

Application

A12B4C3 has been used as an inhibitor of polynucleotide kinase/phosphatase to study its effects on prostate cancer (PC-3) cells.

Biochem/physiol Act...


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Your Price
$218.08 5MG
REQUEST

Not available outside of the UK & Ireland.

Application

A12B4C3 has been used as an inhibitor of polynucleotide kinase/phosphatase to study its effects on prostate cancer (PC-3) cells.

Biochem/physiol Actions

2-(1-hydroxyundecyl)-1- (4-nitrophenylamino)-6-phenyl-6,7a-dihydro-1Hpyrrolo [3,4-b]pyridine-5,7(2H,4aH)-dione (A12B4C3) is a polysubstituted piperidine, that is capable of altering the secondary structure of polynucleotide kinase 3′-phosphatase (PNKP). It functions as an allosterically regulated noncompetitive inhibitor of human PNKP phosphatase activity.

A12B4C3 is a potent and specific hPNKP phosphatase inhibitor. A12B4C3 doubles the radiosensitivity of human A549 lung carcinoma and MDA-MB-231 breast adenocarcinoma cells.

Packaging

5, 25 mg in glass bottle

assay≥98% (HPLC)
coloryellow
formpowder
InChI keyKVHGJAKTBPFFNV-UHFFFAOYSA-N
InChI1S/C30H38N4O5/c1-2-3-4-5-6-7-8-12-15-27(35)26-21-20-25-28(30(37)32(29(25)36)23-13-10-9-11-14-23)33(26)31-22-16-18-24(19-17-22)34(38)39/h9-11,13-14,16-21,25-28,31,35H,2-8,12,15H2,1H3
Quality Level100
SMILES stringCCCCCCCCCCC(O)C1C=CC2C(N1Nc3ccc(cc3)[N+]([O-])=O)C(=O)N(C2=O)c4ccccc4
solubilityDMSO: ≥20 mg/mL
storage temp.2-8°C
Cas Number1005129-80-5
Hazard Class6.1
Un Number2811
Pack Group3
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