Aminopterin, approx.98% (TLC), powder

Code: A1784-100MG D2-231

Not available outside of the UK & Ireland.

Biochem/physiol Actions

Folic acid antagonist. Aminopterin is actively transported into cells by the folate transporter. In the cell, it is converted to a high molecular weig...


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Your Price
$515.59 100MG
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Not available outside of the UK & Ireland.

Biochem/physiol Actions

Folic acid antagonist. Aminopterin is actively transported into cells by the folate transporter. In the cell, it is converted to a high molecular weight polyglutamate metabolite by folylpolyglutamate synthase that, in turn, binds to dihydrofolate reductase and inhibits its activity. Aminopterin-polyglutamate is degraded intracellularly by γ-glutamyl hydrolase.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Linkage

More potent, but more toxic, than methotrexate.

Packaging

1 g in glass bottle

50 mg in glass bottle

ε (extinction coefficient)25,700 at 261 nm in 0.1 M NaOH at 1 M, 8,100 at 373 nm in 0.1 M NaOH at 1 M, 24,500 at 282 nm in 0.1 M NaOH at 1 M
assay≥97% (TLC)
biological sourcesynthetic (organic)
coloryellow
formpowder
Gene Informationhuman ... FPGS(2356)mouse ... Fpgs(14287)
InChI keyTVZGACDUOSZQKY-LBPRGKRZSA-N
InChI1S/C19H20N8O5/c20-15-14-16(27-19(21)26-15)23-8-11(24-14)7-22-10-3-1-9(2-4-10)17(30)25-12(18(31)32)5-6-13(28)29/h1-4,8,12,22H,5-7H2,(H,25,30)(H,28,29)(H,31,32)(H4,20,21,23,26,27)/t12-/m0/s1
mp225 °C
Quality Level200
SMILES stringNc1nc(N)c2nc(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)cnc2n1
solubilityDMSO: soluble (Solutions may be stored for 1-2 days at 4°C.), 2 M NaOH: 50 mg/mL (Solutions may be stored for 1-2 days at 4°C.)
storage temp.−20°C
Cas Number54-62-6
Hazard Class6.1
Un Number2811
Pack Group1
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