Monoclonal anti-ncoa6

Not available outside of the UK & Ireland.

Biochem/physiol Actions

NCOA6 (Nuclear receptor coactivator 6) interacts with nuclear receptors in ligand-dependent or ligand-enhanced dependent manner to regulate nuclear receptor-mediated mammalian gene expression. The activation domain helps to increase the transcriptional activity of several nuclear receptors. It forms a dimer by binding to the liganded receptors, which lead to a structural change in NRC activation. It has also been reported that NCOA6 highly influences the binding of CREB-binding protein (CBP) during transcriptional activity of nuclear hormone receptors.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors. The encoded protein may also act as a general coactivator since it has been shown to interact with some basal transcription factors, histone acetyltransferases, and methyltransferases. (provided by RefSeq)

Immunogen

NCOA6 (NP_054790, 1954 a.a. ~ 2063 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.SequenceVGSHPELLPSIAPSQNLVSKETSTTALQASVARPELEVNAAIVSGQSSEPKEIVEKSKIPGRRNSRTEEPTVASESVENGHRKRSSRPASASSSTKDITSAVQSKRRKSK

Legal Information

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Physical form

Solution in phosphate buffered saline, pH 7.4