Monoclonal anti-brca2

Not available outside of the UK & Ireland.

Biochem/physiol Actions

Breast cancer type 2 susceptibility protein (BRCA2), DNA repair associated protein encodes a protein that promotes homologous recombination, which is essential for normal development. Mutations causes tumor formation and cell lethality. Bi-allelic mutations of BRCA2 is associated with Fanconi anemia (FA). BRCA2 alterations can be used as a prognostic marker for pancreatic cancer.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

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General description

Breast cancer type 2 susceptibility protein (BRCA2), DNA repair associated gene is located on human chromosome 13q13.1. BRCA2and BRCA1 colocalizein subnuclear foci insomatic cellsand on the axial elements of developingsynaptonemal complexes.

Immunogen

BRCA2 (NP_000050, 3319 a.a. ~ 3418 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.SequenceSPQMTPFKKFNEISLLESNSIADEELALINTQALLSGSTGEKQFISVSESTRTAPTSSEDYLRLKRRCTTSLIKEQESSQASTEECEKNKQDTITTKKYI

Legal Information

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Physical form

Solution in phosphate buffered saline, pH 7.4