Anti-WIPI-1 (C-terminal) antibody produced in rabbit, approx. 1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

Not available outside of the UK & Ireland.

Application

Anti-WIPI-1 (C-terminal) antibody produced in rabbit has been used in immunoblotting and immunoprecipitation.

Biochem/physiol Actions

WIPI-1 has essential biological functions including signal transduction, transcription regulation and apoptosis. WD-repeat proteins regulate the assembly of multiprotein complexes by presenting a β-propeller platform for simultaneous and reversible protein-protein interactions. WIPI-1 is linked to starvation-induced autophagy.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

WIPI-1, the mammalian orthologue of Atg18 in S. cerevisiae and A. thaliana, is a member of the WIPI subfamily of WD-repeat proteins. It has a 7-bladed propeller structure and contains a conserved motif for interaction with phospholipids. WIPI-1 is ubiquitously expressed in normal human tissues with highest levels in skeletal muscle, heart and testis. It is aberrantly expressed in human cancer.

Immunogen

synthetic peptide corresponding to amino acids 406-421 of human WIPI-1, conjugated to KLH. The corresponding sequence is identical in mouse and rat.

Physical form

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.