Goat anti-human transforming growth fact or beta soluble receptor iii (tgf-b ri

Not available outside of the UK & Ireland.

Application

Anti-TGF-β sRIII antibody may be used for immunoblotting at a working concentration of 1-2 µg/ml. The antibody may be used for indirect ELISA at a concentration of 0.5-1 µg/ml.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Transforming growth factor-β (TGF-β) belongs to the TGF-β superfamily of secreted proteins. The TGF-β family is involved in a variety of signaling pathways that involve serine/threonine protein kinases. TGF-β acts through binding to three transmembrane receptors in mammals, type I, type II and type III receptors. It is expressed by most cell types and regulates the DNA-binding activity of transcription factors. The important pathways regulated by TGF-β are the SMAD, BMP, MAPK and PI3K/Akt pathways. TGF-β is involved in cell and tissue differentiation, proliferation, morphogenesis, secretion of metalloproteases and inflammation. Deregulation of TGF-β signaling has been implicated in many developmental syndromes and cancer progression Anti-TGF-β sRIII recognizes the extracellular domain of human TGF-β RIII.

Immunogen

recombinant human TGF-β sRIII (betaglycan) expressed in NSO cells

Physical form

Lyophilized from 0.2 µm filtered solution in phosphate buffered saline containing carbohydrates.