Anti-SLC12A3 antibody produced in rabbit, 1 mg/mL, affinity isolated antibody

Not available outside of the UK & Ireland.

Biochem/physiol Actions

This Na-Cl cotransporter is associated with maintaining blood pressure.

Solute carrier family 12 member 3 (SLC12A3) is one of the major components of the sodium chloride reabsorption pathway. It controls the Cl^- concentration and is also involved in the transepithelial ion absorption and secretion. Mutations in the gene encoding SLC12A3 have been associated with Gitelman syndrome.

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General description

Solute carrier family 12 member 3 (SLC12A3) is also known as thiazide-sensitive Na⁺-Cl^- cotransporter (NCCT). It is expressed in the apical cells of the distal convoluted tubule. The gene encoding this 1021 amino acid protein is localized on human chromosome 16q13. The gene ID for the protein is 6559.

Immunogen

AA74-95 (rat), 76-97 (hum)

Physical form

PBS, 50% glycerol, and 0.09% sodium azide

Specificity

Detects ~160 kDa.