Anti-HSPB2 antibody produced in rabbit, 1 mg/mL, affinity isolated antibody

Not available outside of the UK & Ireland.

Biochem/physiol Actions

Heat shock protein family B, member 2 (HSPB2) binds to ubiquitin and hydrogen peroxide-inducible clone 5, an adaptor protein. This association is important for the ubiquitination and degradation of NADPH oxidase 4 (Nox4). It is also crucial for the degradation of other proteins. HSPB2 interacts with myotonic dystrophy protein kinase (DMPK) and activates it.

Features and Benefits

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General description

Heat shock protein family B, member 2 (HSPB2) is also called as myotonic dystrophy kinase binding protein (MKBP). It is expressed in the skeletal muscles and heart. Studies have also shown that HSPB2 is overexpressed in lung fibrosis. The gene encoding it is localized on human chromosome 11q22-q23. The gene ID of the protein is 3316.

Immunogen

Synthetic peptide

Physical form

PBS, 50% glycerol, and 0.02% sodium azide

Specificity

Detects ~27 kDa.