Monoclonal Anti-CD4-FITC , (N-terminal) antibody produced in mouse, clone MEM-241, purified immunoglobulin, buffered aqueous solution

Not available outside of the UK & Ireland.

Application

The reagent is designed for Flow Cytometry analysis of human blood cells using 20 µL reagent / 100 µL of whole blood or 1e6 cells in a suspension. The content of a vial (2 mL) is sufficient for 100 tests.

Biochem/physiol Actions

Cluster of differentiation 4 (CD4) facilitates the activation of immunostimulatory T-cells. It serves as a primary receptor for human immunodeficiency virus (HIV)-1 entry. The encoded protein also plays a key role in altering cell elasticity. Elevated expression of soluble CD4 has been observed in patients of infectious and chronic inflammatory diseases and rheumatoid arthritis (RA). Thus, this protein can be used as a potential diagnostic marker for the development of RA.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

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General description

Cluster of differentiation 4 (CD4) molecule is encoded by the gene mapped to human chromosome 12p13.31. The encoded protein is mainly localized on the surface of specific leukocytes. CD4 is characterized with a four ecto-domains (D1-D4) of which D1, D2 and D4 contain disulfide bonds.

The antibody MEM-241 recognizes CD4 antigen, a 55 kDa transmebrane glycoprotein expressed on a subset of T lymphocytes ("helper" T-cells) and also on monocytes, tissue macrophages and granulocytes.

Immunogen

2 N-terminal domains of human CD4 fused to human IgG1 Fc

Physical form

Solution in phosphate buffered saline containing 15 mM sodium azide and 0.2% high-grade protease free BSA as a stabilizing agent.