Anti-phospho-VE-Cadherin (pTyr731) antibody produced in rabbit, approx. 1 mg/mL, affinity isolated antibody, buffered aqueous solution

Not available outside of the UK & Ireland.

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.Western Blotting (1 paper)

Biochem/physiol Actions

Cadherin 5 (CDH5) plays an essential role in various cellular processes, such as regulation of cell adhesion, cell proliferation, cell survival, cell shape, cell motility, modulation of signaling pathways and transcriptional gene regulation. Cdh5/VE(vascular endothelial)-cadherin is a core component of endothelial adherens junction, which plays a vital role in angiogenic sprouting by enhancing cell migration and cell elongation. CDH5 expressed in glioblastoma multiforme (GBM), facilitates the transdifferentiation of glioblastoma stem-like cells (GSCs) to endothelial cells and to form blood vessels, under hypoxia condition. VE-cadherin induces endothelial cell-cell adhesion at adherens junctions (AJs). CDH5 gene knockout results in loss of cell polarity and modification in vascular lumenal structure. CDH5 inhibits the synthesis of CDH2 (also known as N-cadherin) in the endothelium.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

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General description

Cadherin 5 (CDH5) is encoded by the gene mapped to long arm of human chromosome 16. The encoded protein is expressed in endothelial cells, but it is absent in normal epithelium.

Immunogen

The antiserum was produced against synthesized peptide derived from human VE-Cadherin around the phosphorylation site of Tyr731.Immunogen Range: 697-746

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.