Anti-phospho-FRS2 (pTyr436) antibody produced in rabbit, approx. 1 mg/mL, affinity isolated antibody, buffered aqueous solution

Not available outside of the UK & Ireland.

Biochem/physiol Actions

Fibroblast growth factor (FGF) receptor substrate 2 (FRS2) is essential for activation of downstream signaling molecules that are involved in the MAP (‎mitogen-activated protein kinase) and AKT (protein kinase B) kinase pathways. This protein plays an important role in epidermal growth factor (EGF) signaling. It also plays a major role in cell transformation and resistance to therapy. FRS2 helps to link FGF, nerve growth factor (NGF) and glial cell-derived neurotrophic factor (GDNF) receptors with the Ras/mitogen-activated protein (MAP) kinase signaling cascade.

Disclaimer

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General description

Fibroblast growth factor (FGF) receptor substrate 2 (FRS2) is an FGF receptor (FGFR)-associated protein. It is a membrane-bound adaptor protein, that is located on human chromosome 12q15.

Immunogen

The antiserum was produced against synthesized peptide derived from human FRS2 around the phosphorylation site of Tyr436.Immunogen Range: 402-451

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.